A novel, simple, accurate, precise andreproducibleUV- Spectrometricmethod has been developed for simultaneous estimationof Clonazepam and Paroxetine hydrochloride hemihydrate in capsule formulation. Clonazepam and Paroxetine hydrochloride hemihydrate in combinedcapsule formulation were estimated using the Area Under Curve (AUC) method at 304 - 314 nm for Clonazepam and 290 - 300 nm for Paroxetine hydrochloride hemihydrate in their methanolic solution. The linearity was found in the concentration range of 0.4- 3.6 µg/ml for Clonazepam and 10- 90 µg/ml for Paroxetine hydrochloride hemihydrate. The method was validated bylinearity, LOD, LOQ, accuracy, precision, robustness and ruggedness for both Clonazepam and Paroxetine hydrochloride hemihydrate.This method can be used for the routine simultaneous estimation of Clonazepam and Paroxetine hydrochloride hemihydrate in industries and other analytical laboratories.
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